71 CONGRESO AEP. Libro de comunicaciones

876 ISBN: 978-84-09-79209-2 ÁREA DE ESPECIALIDAD (MEDICINA PEDIÁTRICA)  OTROS #2142 COMUNICACIÓN ORAL ¿Proteinuria in pediatric obese patients – is there a correlation? Marta Carvalho, Armanda Rebelo, Catarina Neves, Nádia Brito, Filipa Inês Cunha Hospital Distrital da Figueira da Foz, Figueira da Foz, Portugal INTRODUCCIÓN Y OBJETIVOS The prevalence of obesity and of end-stage renal disea- se has been steadily increasing over the past few decades. Obesity has been associated with glomerular changes, through a condition called obesity-related glomerulopathy, whose most common clinical presentation is proteinuria. Most studies report the identification of proteinuria in obe- se patients using a 24-hour urine collection, but due to the difficulty in obtaining this sample, an occasional urine sam- ple is often used instead. The aim of this study is to analyse the incidence of pro- teinuria in obese patients followed at our hospital and com- pare it with the severity and duration of obesity. MÉTODOS Transversal study including obese patients (BMI zscore ≥2) between 5 and 17 years old evaluated in the outpatient setting at our hospital from January to July 2022, whose parents consented to this analysis. Patients with hyperten- sion or diabetes were excluded. An occasional urine sample was collected and protein-to-creatinine ratio (PTCR) was evaluated. A PTCR ≥0.2mg/mg was considered positive for proteinuria only if confirmed in a first void urine sample. Statistical analysis was performed using SPSS v26.0, with statistically significance for p <0.05. RESULTADOS We included 136 patients, 59% male, with median age of 10.6 years old (interquartile range (IQR): 5.65). The me- dian BMI zscore was 2.70 (IQR: 0.79) and the median dura- tion of obesity was 4 years (IQR: 4). No cases of proteinuria were identified, with a median PTCR of 0.09mg/mg (IQR: 0.05). We found a positive correlation between PTCR and BMI zscore, but without statistically significance (p = 0.781) and a statistically significant negative correlation was iden- tified between PTCR and the duration of obesity (p <0.001). CONCLUSIONES In our sample, no positive cases of proteinuria were identified. Although a negative correlation was found bet- ween PTCR and duration of obesity, it is difficult to draw a conclusion, as in all cases PTCR was within the normal ran- ge, which can suggest the possibility of an activation of an adaptative response. Therefore, it is important to regularly evaluate markers of kidney damage in obese patients, being essential to identify easily applicable methods, ideally using an occasional urine sample instead of a 24-hour collection to increase patient adherence.